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For coronary artery disease, where partial blockages reduce blood flow to heart muscle, enhanced collateral development could improve myocardial perfusion

References Ashida H, Suzuki N, Tanabe T, Suzuki N, Aonuma Y (2015) Reproductive condition, batch fecundity, and spawning fraction of large Pacific bluefin tuna Thunnus orientalis landed at Ishigaki Island, Okinawa, Japan

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The former provides rapid onset GH release while the latter acts to raise GH secretion over longer periods and maintain normal physiologic secretion patterns [8], [9]